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KMID : 1094720230280050781
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Biotechnology and Bioprocess Engineering
2023 Volume.28 No. 5 p.781 ~ p.789
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Multi-bioinspired Sprayable Nanotherapeutics for Tumor-Specific Focal Cancer Therapy
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Jeon Yu-Ri
Jo Yun-Kee
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Abstract
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Chemotherapy is commonly used to treat cancer. However, insufficient retention at the target site and systemic toxicity remains critical challenges. Chitosan has attracted considerable attention as a carrier backbone for delivering therapeutic cargos because of its biocompatibility and mucoadhesive property. However, pH and concentration-dependent solubility of chitosan has been restricted further applications to clinical settings. Inspired by marine mussels and crustaceans, in this study, we present chitosan-based nanoparticles containing catechol?Fe3+ complexes (Cat-CS NPs) as a tumor-activatable delivery system to achieve highly efficient locoregional treatment of cancer via a simple spray process while minimizing adverse effects towards surrounding normal tissues. Cat-CS NPs were fabricated through electrospraying and exhibited superior adhesiveness on substrates in aqueous conditions in a surface-independent manner. The pH-responsive stoichiometry of catechol?Fe3+ coordination in doxorubicin (DOX)-loaded Cat-CS NPs (Cat-CS@DOX NPs) enabled a triggered release of DOX in response to acidic conditions around tumor tissues. The sprayed Cat-CS@DOX NPs significantly inhibited cancer cell growth in vitro while exhibiting good biocompatibility towards normal cells. Taken together, Cat-CS NP-based sprayable nanotherapeutics can be used as a locoregional delivery system, especially in adjuvant cancer therapy.
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KEYWORD
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catechol-chitosan conjugate, adhesive nanoparticles, surgical spray, metal coordination, adjuvant cancer therapy
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